Loteprednol etabonate

Research use only, not for human use.

Loteprednol etabonate is an anti-inflammatory corticosteroid used in optometry and ophthalmology.

Loteprednol etabonate is an anti-inflammatory corticosteroid used in optometry and ophthalmology.Allergy Approved(In Vitro):Intravenous administration of Loteprednol etabonate (5 mg/kg) to dogs reveals a terminal half-life of 2.8 h, a volume of distribution of 3.7 L/kg, and a total body clearance of 0.9 L/h/kg. Intact loteprednol etabonate was not detectable in the urine. After oral administration of the drug (5 mg/kg) to dogs, only metabolites, but no intact drug, were found in the plasma, an indication for a high first-pass effect.

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Intravenous administration of Loteprednol etabonate (5 mg/kg) to dogs reveals a terminal half-life of 2.8 h, a volume of distribution of 3.7 L/kg, and a total body clearance of 0.9 L/h/kg. Intact loteprednol etabonate was not detectable in the urine. After oral administration of the drug (5 mg/kg) to dogs, only metabolites, but no intact drug, were found in the plasma, an indication for a high first-pass effect.

Loteprednol Etabonate | Lotemax | Alrex | HGP-1 | Loterox | Locort

Endocrinology/Hormones

GR

GlucocorticoidReceptor

Inflammation/Immunology

Allergy

82034-46-6

466.9518

C24H31ClO7

>98% (HPLC)

DMSO: ≥ 45 mg/mL

O=C([C@@]1(OC(OCC)=O)CC[C@@]2([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C)=O)OCCl

Androsta-1,4-diene-17-carboxylic acid, 17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-, chloromethyl ester, (11β,17α)-

(-20℃)

With Ice Pack

≥ 2 years